James Hamilton, Lord Paisley (d. bef. 1670) was the eldest son of James Hamilton, 2nd Earl of Abercorn and Katherine Clifton, 2nd Baroness Clifton.
On 28 April 1653, in London, he married Catherine Lenthall, niece of William Lenthall, Speaker of the Long Parliament. They had one daughter:
The Bodleian Library preserves one of his letters, from 1660, asking his uncle Sir George Hamilton, 1st Baronet for some preferment at the Restoration. However, he died before his father, so that his brother George succeeded as Earl of Abercorn.